U2M2 is the key multidepartmental and interdisciplinary engine for the clinical departments. U2M2 investigators have primary appointments in clinical departments and lead research programs that advance translational science by catalyzing the development, testing, and implementation of new diagnostics and therapeutics for a variety of human diseases and conditions. U2M2 is located in the Eccles Institute of Human Genetics alongside the Department of Human Genetics. U2M2 provides core faculty that lead the Research Education Core of the CTSA, the MD-PhD program, the Summer Medical Research program, the HHMI Med to Grad PhD track, the NIH Heart Failure Clinical Research Network and the Metabolism Interest Group. U2M2 directs the T-32 in Cardiovascular Research and the T-32 in Metabolism. These T-32s are integrated with the CTSA, MD-PhD program and the Med to Grad track and, as such, serve as templates for T-32s across the clinical and basic science departments.