My research investigates the pathophysiology and treatment of diabetes and it complications. More specifically we study insulin action, tissue specific cross-talk, complications of diabetes, and hormonal counterregulation.

Interdisciplinary Research Environment

Our laboratory provides a rich interactive and interdisciplinary research environment for fostering the scientific development of the postdoctoral fellows, clinical fellows, MSTP students, PhD students, and undergraduate medical students who wish to pursue scientific careers dedicated to diabetes research.

Prada PO, Goto M, Chiappini F, Reno CM, Martin TL, Gautron L, PulinilkunnilT, Lee A, Fisher SJ, Peroni OD, Kahn BB (In Press). Hypothalamic GLUT4 Regulates Food Intake, Energy Balance and Glucose Sensing. J Clin Invest.

Reno CM, Puente EC, Sheng Z, Daphna-Iken D, Bree AJ, Routh VH, Kahn BB, Fisher SJ (2017). Brain GLUT4 Knockout Mice Have Impaired Glucose Tolerance, Decreased Insulin Sensitivity, and Impaired Hypoglycemic Counterregulation. Diabetes, 66(3), 587-597.

Clark AL, Best CJ, Fisher SJ (May 2014). Even silent hypoglycemia induces cardiac arrhythmias. Diabetes.

McGill JB, Vlajnic A, Knutsen PG, Recklein C, Rimler M, Fisher SJ (2013). Effect of gender on treatment outcomes in type 2 diabetes mellitus. Diabetes Res Clin Pract, 102(3), 167-74.

Reno CM, Daphna-Iken D, Chen YS, VanderWeele J, Jethi K, Fisher SJ (2013). Severe hypoglycemia-induced lethal cardiac arrhythmias are mediated by sympathoadrenal activation. Diabetes, 62(10), 3570-81.

Reno CM, Tanoli T, Bree A, Daphna-Iken D, Cui C, Maloney SE, Wozniak DF, Fisher SJ (2013). Antecedent glycemic control reduces severe hypoglycemia-induced neuronal damage in diabetic rats. Am J Physiol Endocrinol Metab, 304(12), E1331-7.

Litvin M, Clark AL, Fisher SJ (2013). Recurrent hypoglycemia: boosting the brain’s metabolic flexibility. J Clin Invest, 123(5), 1922-4.

Reno CM, Litvin M, Clark AL, Fisher SJ (2013). Defective counterregulation and hypoglycemia unawareness in diabetes: mechanisms and emerging treatments. [Review]. Endocrinol Metab Clin North Am, 42(1), 15-38.

Joshi PM, Fisher SJ (2013). Pheochromocytoma. In TJ Baranski, WE Clutter, and JB McGill (Eds.), The Washington Manual, Endocrine Subspecialty Consult (3rd Edition, pp. 108-20). WoltersKluwer | Lippincott Williams & Wilkins.

Bao S, Fisher SJ (2013). Adrenal Incidentaloma. In TJ Baranski, WE Clutter, and JB McGill (Eds.), The Washington Manual, Endocrine Subspecialty Consult (3rd Edition, pp. 69-73). WoltersKluwer | Lippincott Williams & Wilkins.

Bao S, Oiknine R, Fisher SJ (2012). Differentiating nonthyroidal illness syndrome from central hypothyroidism in the acutely ill hospitalized patient [Letter to the editor]. Endocrine, 42(3), 758-60.

Bao SS, Fisher SJ (2012). Repairing a “broken heart” with hormone replacement therapy: case report of cardiogenic shock due to undiagnosed pituitary insufficiency. Endocr Pract, 18(2), e26-31.

Purcell SH, Aerni-Flessner LB, Willcockson AR, Diggs-Andrews KA, Fisher SJ, Moley KH (2011). Improved insulin sensitivity by GLUT12 overexpression in mice. Diabetes, 60(5), 1478-82.

Silverstein JM, Musikantow D, Puente EC, Daphna-Iken D, Bree AJ, Fisher SJ (2011). Pharmacologic amelioration of severe hypoglycemia-induced neuronal damage. Neurosci Lett, 492(1), 23-8.

Zhou Y, Lee J, Reno CM, Sun C, Park SW, Chung J, Lee J, Fisher SJ, White MF, Biddinger SB, Ozcan U (2011). Regulation of glucose homeostasis through a XBP-1-FoxO1 interaction. Nat Med, 17(3), 356-65.

Scherer T, OHare J, Diggs-Andrews K, Schweiger M, Cheng B, Lindtner C, Zielinski E, Vempati P, Su K, Dighe S, Milsom T, Puchowicz M, Scheja L, Zechner R, Fisher SJ, Previs SF, Buettner C (2011). Brain insulin controls adipose tissue lipolysis and lipogenesis. Cell Metab, 13(2), 183-94.

Fisher SJ (2011). Commentary. Clin Chem, 57(2), 157.

Diggs-Andrews KA, Zhang X, Song Z, Daphna-Iken D, Routh VH, Fisher SJ (2010). Brain insulin action regulates hypothalamic glucose sensing and the counterregulatory response to hypoglycemia. Diabetes, 59(9), 2271-80.

Wice BM, Wang S, Crimmins DL, Diggs-Andrews KA, Althage MC, Ford EL, Tran H, Ohlendorf M, Griest TA, Wang Q, Fisher SJ, Ladenson JH, Polonsky KS (2010). Xenin-25 potentiates glucose-dependent insulinotropic polypeptide action via a novel cholinergic relay mechanism. J Biol Chem, 285(26), 19842-53.

Puente EC, Silverstein J, Bree AJ, Musikantow DR, Wozniak DF, Maloney S, Daphna-Iken D, Fisher SJ (2010). Recurrent moderate hypoglycemia ameliorates brain damage and cognitive dysfunction induced by severe hypoglycemia. Diabetes, 59(4), 1055-62.

Brubaker PL, Cherrington AD, Finegood DT, Fisher SJ, Giacca A, Marette A, Riddell MC, Wasserman D (2010). Proceedings of a symposium to honour Mladen Vranic for a lifetime of scientific achievements and mentoring. Canadian Journal of Diabetes, 34(3), 186-202.

Bree AJ, Puente EC, Daphna-Iken D, Fisher SJ (2009). Diabetes increases brain damage caused by severe hypoglycemia. Am J Physiol Endocrinol Metab, 297(1), E194-201.

Haywood SC, Bree AJ, Puente EC, Daphna-Iken D, Fisher SJ (2009). Central but not systemic lipid infusion augments the counterregulatory response to hypoglycemia. Am J Physiol Endocrinol Metab, 297(1), E50-6.

Ishihara KK, Haywood SC, Daphna-Iken D, Puente EC, Fisher SJ (2009). Brain insulin infusion does not augment the counterregulatory response to hypoglycemia or glucoprivation. Metabolism, 58(6), 812-20.

Diggs-Andrews K, Silverstein J, Fisher SJ (2009). Glucose regulation in the central nervous system [Web]. interMDnet Corporation. Available:

Puente E, Tanoli T, Fisher SJ (2009). Hypoglycemia and the central nervous system. In T. Hughes (Ed.), US Endocrinology (7th edition). Touch Briefings.

Fisher SJ, Bruning JC, Lannon S, Kahn CR (2005). Insulin signaling in the central nervous system is critical for the normal sympathoadrenal response to hypoglycemia. Diabetes, 54(5), 1447-51.

Jimenez-Chillaron JC, Hernandez-Valencia M, Reamer C, Fisher S, Joszi A, Hirshman M, Oge A, Walrond S, Przybyla R, Boozer C, Goodyear LJ, Patti ME (2005). Beta-cell secretory dysfunction in the pathogenesis of low birth weight-associated diabetes: a murine model. Diabetes, 54(3), 702-11.

Chen D, Mauvais-Jarvis F, Bluher M, Fisher SJ, Jozsi A, Goodyear LJ, Ueki K, Kahn CR (2004). p50alpha/p55alpha phosphoinositide 3-kinase knockout mice exhibit enhanced insulin sensitivity. Mol Cell Biol, 24(1), 320-9.

Norris AW, Chen L, Fisher SJ, Szanto I, Ristow M, Jozsi AC, Hirshman MF, Rosen ED, Goodyear LJ, Gonzalez FJ, Spiegelman BM, Kahn CR (2003). Muscle-specific PPARgamma-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones. J Clin Invest, 112(4), 608-18.

Vicent D, Ilany J, Kondo T, Naruse K, Fisher SJ, Kisanuki YY, Bursell S, Yanagisawa M, King GL, Kahn CR (2003). The role of endothelial insulin signaling in the regulation of vascular tone and insulin resistance. J Clin Invest, 111(9), 1373-80.

Fisher SJ, Kahn CR (2003). Insulin signaling is required for insulin’s direct and indirect action on hepatic glucose production. J Clin Invest, 111(4), 463-8.

Fisher SJ, Kahn CR (2002). Physiological mechanisms in homeostatic control of glucose. In M Besser, M Thorner (Eds.), Comprehensive Clinical Endocrinology (3rd Ed.). Harcourt Publishers Limited.

Fisher SJ, Shi ZQ, Lickley HL, Efendic S, Vranic M, Giacca A (2001). Low-dose IGF-I has no selective advantage over insulin in regulating glucose metabolism in hyperglycemic depancreatized dogs. J Endocrinol, 168(1), 49-58.

Kreisman SH, Manzon A, Nessim SJ, Morais JA, Gougeon R, Fisher SJ, Vranic M, Marliss EB (2000). Glucoregulatory responses to intense exercise performed in the postprandial state. Am J Physiol Endocrinol Metab, 278(5), E786-93.

Sigal RJ, Fisher SJ, Manzon A, Morais JA, Halter JB, Vranic M, Marliss EB (2000). Glucoregulation during and after intense exercise: effects of alpha-adrenergic blockade. Metabolism, 49(3), 386-94.

Sigal RJ, Fisher SJ, Halter JB, Vranic M, Marliss EB (1999). Glucoregulation during and after intense exercise: effects of beta-adrenergic blockade in subjects with type 1 diabetes mellitus. J Clin Endocrinol Metab, 84(11), 3961-71.

Lekas MC, Fisher SJ, El-Bahrani B, van Delangeryt M, Vranic M, Shi ZQ (1999). Glucose uptake during centrally induced stress is insulin independent and enhanced by adrenergic blockade. J Appl Physiol (1985), 87(2), 722-31.

Marliss EB, Sigal RJ, Fisher SJ, Manzon A, Halter JB, Vranic M (1995). Glucoregulation in intense exercise and its implications for persons with diabetes mellitus. In Kawamori R, Vranic M, Horton ES, Kubota M (Eds.), Glucose Fluxes, Exercise and Diabetes (pp. 55-66). Great Britain: Smith-Gordon.

Manzon A, Fisher SJ, Morais JA, Lipscombe L, Guimond MC, Nessim SJ, Sigal RJ, Halter JB, Vranic M, Marliss EB (1998). Glucose infusion partially attenuates glucose production and increases uptake during intense exercise. J Appl Physiol (1985), 85(2), 511-24.

Fisher SJ, Lekas M, Shi ZQ, Bilinski D, Carvalho G, Giacca A, Vranic M (1997). Insulin-independent acute restoration of euglycemia normalizes the impaired glucose clearance during exercise in diabetic dogs. Diabetes, 46(11), 1805-12.

Giacca A, Fisher SJ, McCall RH, Shi ZQ, Vranic M (1997). Direct and indirect effects of insulin in suppressing glucose production in depancreatized dogs: role of glucagon. Endocrinology, 138(3), 999-1007.

Shilyansky J, Fisher S, Cutz E, Perlman K, Filler RM (1997). Is 95% pancreatectomy the procedure of choice for treatment of persistent hyperinsulinemic hypoglycemia of the neonate? J Pediatr Surg, 32(2), 342-6.

Fisher SJ, Shi ZQ, Lickley HL, Efendic S, Vranic M, Giacca A (1996). A moderate decline in specific activity does not lead to an underestimation of hepatic glucose production during a glucose clamp. Metabolism, 45(5), 587-93.

Fisher SJ, Lekas MC, McCall RH, Shi ZQ, Giacca A, Vranic M (1996). Determinants of glucose turnover in the pathophysiology of diabetes: an in vivo analysis in diabetic dogs. [Review]. Diabetes Metab, 22(2), 111-21.

Sigal RJ, Fisher S, Halter JB, Vranic M, Marliss EB (1996). The roles of catecholamines in glucoregulation in intense exercise as defined by the islet cell clamp technique. Diabetes, 45(2), 148-56.

Shi ZQ, Fisher SJ, Giacca A, Efendic S, van de Werve G, Vranic M (1995). Are some of the adaptive effects of hyperglycemia beneficial in diabetes? In Kawamori R, Vranic M, Horton ES, Kubota M (Eds.), Glucose Fluxes, Exercise and Diabetes (pp. 117-23). Great Britain: Smith-Gordon.

Fisher SJ, Shi ZQ, Lekas M, Giacca A, Vranic M (1995). Role of hyperglycemia in regulating glucose uptake by the diabetic muscle during exercise. In Baba S, Kaneko T (Eds.), Diabetes (pp. 477-83). Amsterdam: Elsevier Science B.V.

Shi ZQ, Giacca A, Fisher S, Vidal H, van de Werve G, Vranic M (1994). Importance of substrate changes in the decrease of hepatic glucose cycling during insulin infusion and declining glycemia in the depancreatized dog. Diabetes, 43(11), 1284-90.

Sigal RJ, Purdon C, Fisher SJ, Halter JB, Vranic M, Marliss EB (1994). Hyperinsulinemia prevents prolonged hyperglycemia after intense exercise in insulin-dependent diabetic subjects. J Clin Endocrinol Metab, 79(4), 1049-57.

Giacca A, Fisher SJ, Shi ZQ, Gupta R, Lickley HL, Skottner A, Anderson GH, Efendic S, Vranic M (1994). Insulin-like growth factor-I and insulin have no differential effects on glucose production and utilization under conditions of hyperglycemia. Endocrinology, 134(5), 2251-8.

Shi ZQ, Giacca A, Yamatani K, Fisher SJ, Lickley HL, Vranic M (1993). Effects of subbasal insulin infusion on resting and exercise-induced glucose turnover in depancreatized dogs. Am J Physiol, 264(3 Pt 1), E334-41.

Shi ZQ, Giacca A, Fisher SJ, Lekas M, Bilinski D, Van Delangeryt M, Lickley HL, Vranic M (1993). Indirect effects of insulin in regulating glucose fluxes. [Review]. Adv Exp Med Biol, 334, 151-68.

Shi ZQ, Giacca A, Fisher S, M Lekas, Bilinski D, Van Delangeryt M, Lickley L, Vranic M (1993). Indirect effects of insulin in regulating glucose production in postabsorptive state and glucose fluxes during exercise. In Efendic S, Ostenson C, Vranic M (Eds.), New Concepts in the Pathogenesis of NIDDM. Advances in Experimental Biology and Medicine (334, pp. 151-168). New York and London: Plenum Press.

Vranic M, Kawamori R, Shi ZQ, Giacca A, Fisher S, Marliss E, Yamatani K, Marette A, Dimitrakoudis D, Klip A (1993). Metabolic differences between moderate and strenuous exercise. From the viewpoint of glucose fluxes and hormonal effects to the regulation of glucose transporters. In The Fourth International Symposium on Exercise for Diabetes Practice (Supplement #1, pp. 3-23).

Giacca A, Fisher SJ, Shi ZQ, Gupta R, Lickley HL, Vranic M (1992). Importance of peripheral insulin levels for insulin-induced suppression of glucose production in depancreatized dogs. J Clin Invest, 90(5), 1769-77.

Yamatani K, Shi ZQ, Giacca A, Gupta R, Fisher S, Lickley HL, Vranic M (1992). Role of FFA-glucose cycle in glucoregulation during exercise in total absence of insulin. Am J Physiol, 263(4 Pt 1), E646-53.

Shi ZQ, Giacca A, Yamatani K, Miles PDG, Fisher S, Van Delangeryt M, Lickley HLA, Vranic M (1992). Chapter 8: Glucose uptake in exercise and stress: The indirect role of insulin. In Devlin J, Horton ES , Vranic M (Eds.), Diabetes Mellitus and Exercise Symposium. London, England: Smith-Gordon.

Principle Investigator


Simon Fisher, MD, PH.D.

Simon Fisher received his MD and PhD from the University of Toronto. He completed his residency and fellowship in Internal Medicine at the Beth Israel Deaconess Medical Center at Harvard Medical School. He came to the University of Utah from Washington University School of Medicine, where he was an associate professor of Medicine, Cell Biology and … Read More

Specialties: Endocrinology & Metabolism


Phone: 801-581-7761


Profile Page

Lab Members


Adriana Vieira de Abreu

Title: Senior Lab Specialist

Education: PhD, Oswaldo Cruz Foundation, RJ – Brazil

Research: Hypoglycemia Unawareness

Hobbies: Traveling, running, and swimming



Rahul Agrawal

Title: Post-Doctoral Fellow

Education: Ph.D. from University of Lucknow, U.P., India

Title: Research Associate

Research: Study the mechanism of insulin action in the brain and to identify the approaches to restore sympathoadrenal response to hypoglycemia

Hobbies: Driving, hiking & watching movies



Candace Reno

Title: Post-Doctoral Fellow

Education: PhD, Washington University in St. Louis

Research: Severe hypoglycemia-induced cardiac arrhythmias

Hobbies: Diving with sharks



Justin Bayles

Title: Undergraduate Student

Education: Biology Major

Research: Preventing sudden death during severe hypoglycemia

Hobbies: Hiking, Photography, Learning new Cultures, Watching sports and Travel



Yu Kuei (Alex) Lin

Title: Assistant Professor of Medicine (Clinical)

Education: MD, Poznan University of Medical Sciences – Poland

Research: Hypoglycemia and cardiac arrhythmia

Hobbies: Reading, spending time with family



Griffin Durupt

Education: Undergraduate, Kinesiology Major, Chemistry Minor

Research: Been with Fisher lab for a year and a half. Have been doing clinical research at the University Hospital Emergency Department for 2 years

Hobbies: Playing soccer, running, volunteering with U-fit


Emily Huang

Education: Biology Major

Research: Preventing sudden death during severe hypoglycemia

Hobbies: Traveling, reading, hiking and movies



Michael Gregory Montgomery

Education: Undergraduate, Chemistry Major

Research: miRNA and its effect on counter regulation to hypoglycemia

Hobbies: Cooking, Hiking, Sports, and Watching Movies



Ethan Meier

Education: Undergraduate Biology/Computer Science Major, International Baccalaureate Diploma

Hobbies: Singing, Reading, Writing



Milan Oxspring

Education: B.S. Kinesiology, Minor Chemistry; B.S. Health, Society, and Policy

Research: Preventing fatal cardiac arhythmias during severe hypoglycemia

Hobbies: Following sports, traveling, exercising, eating


Former Members

Hannah Kallaker – Summer 2018
Parker Gordon Howe – 2017-2018
Casey Taylor – 2017
Rana Smalling – 2016-2018
Allie Skinner – 2015-2017
David Jackson – 2015-2017
Trevin Michael – 2015-2017
Jinze Li – 2015-2016
Katya Markova – 2015-2016
Nilma Malik – 2015-2016
Wayne Nez – Summer 2015

Phone Numbers

Dr. Simon Fisher: (801) 585-3353

Lab Phone Number: (801) 585-9433

Mailing Address

Please send all mail to Dr. Simon Fisher at the address below:

Simon Fisher, MD, PhD
University of Utah
EIHG Building 533, Room 2110

15 North 2030 East
Salt Lake City, UT  84112

Intracampus mail: EIHG Building (bldg 533)

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Get directions to the Eccles Institute of Human Genetics from the Salt Lake City airport.

Campus Shuttle Map & Schedule

The University of Utah provides a free campus shuttle.