Welcome to the Schlegel Laboratory. Located in the the Eccles Institute of Human Genetics on the University of Utah’s School of Medicine campus. We are a research enterprise focused on understanding metabolic diseases with particular attention to disorders marked by abnormal lipid synthesis, transport, and storage.
Image: An adult zebrafish stained with Oil Red O to reveal the subcutaneous adipose depots.
The Schlegel Laboratory at the University of Utah School of Medicine is a research environment focused on metabolic diseases. We use zebrafish genetics and physiology to identify and characterize novel genes involved in lipid homeostasis. Our strategy involves positionally cloning the mutated genes and then characterizing their function. Reverse genetic methods (TALEN technology) are also used in select cases to address hypothesis-driven questions.